• 名称: Su-DHL-6(人B细胞淋巴瘤)
  • 货号: CBP60993
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CBP60993
I. General information 
Synonyms: Su-DHL-6
Background: The DHL cell lines were successfully established in continuous suspension culture from 10 patients with a histopathological diagnosis of diffuse histiocytic lymphoma (DHL).
Species: Homo sapiens, human
Tissue: peritoneal effusion; derived from metastatic site: peritoneal cavity
Disease: large cell lymphoma; diffuse mixed histiocytic and lymphocytic lymphoma; follicular B cell lymphoma
Gender: male, Caucasian
Morphology: lymphoblast-like
Growth Mode: suspension
Doubling Time: approximately 29 hours
DNA Profile: D5S818: 12
D13S317: 12,14
D7S820: 10
D16S539: 11,12
vWA: 14,17
THO1: 6,9.3
TPOX: 11,12
CSF1PO: 10
Amelogenin: X
Cobioer’s Cell Line Authentication Service
Culture Medium: RPMI-1640+10%FBS
We strongly suggest to purchase the complete medium from Cobioer.
Cryopreservation medium: 90%FBS+10%DMSO
Genes Expressed: monoclonal cytoplasmic immunoglobulin: IgM; lambda light chain
Comments: All of the DHL cell lines were negative for the presence of Epstein-Barr virus (EBV) genomes.
SU-DHL-6 possesses a t(14;18)(q32;q21) translocation and demonstrates an unexpected recombination within its heavy chain gene locus that may be the interchromosomal breakpoint.
In SU-DHL-6, the t(14;18) translocation juxtaposes a truncated bcl-2 gene with J6 in a tail-to-head configuration.
The deregulated expression of the altered bcl-2 gene may play a critical role in the disordered growth and differentiation of follicular B cell lymphoma.
For more information, please contact Cobioer (4008-750-250).

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