• 名称: FLT3-ITD [D835Y]/BaF3
  • 货号: CBP73098
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CBP73098
I. Introduction

Cell Line Name:

FLT3-ITD [D835Y]/BaF3

Gene Synonyms:

FLT3

Host Cell:

Ba/F3

Stability: 16 passages

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

 
II.Background

FLT3, receptor-type tyrosine-protein kinase FLT3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385).

 
III. Representative Data

1.FLT3-ITD [D835Y]/BaF3

 

2. Anti-proliferation assay

 

Figure . Anti-proliferation assay of two reference compounds on the FLT3-ITD [D835Y]/BaF3 Stable Cell Line.

 

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