• 名称: Her2 WT/BaF3
  • 货号: CBP73110
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CBP73110
I. Introduction

Cell Line Name:

Her2 WT/BaF3

Gene Synonyms:

NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu

Host Cell:

Ba/F3

Stability: 16 passages

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10% FBS

Mycoplasma Status:

Negative

 
II.Background

ERBB2 (HER2), erb-b2 receptor tyrosine kinase 2, is an EGFR receptor tyrosine kinase that activates PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways, therefore regulating growth and transformation (PMID: 17471238). ERBB2 (HER2) amplification, overexpression, and activation has been implicated in several tumor types (PMID: 17471238).

 
III. Representative Data

1. WB of Her2 WT/BaF3

2. Anti-proliferation assay

 

Figure 2. Anti-proliferation assay of two reference compounds on the Ba/F3_HER2 WT Stable Cell line.

 

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