• 名称: TEL(ETV6)-JAK2/BaF3
  • 货号: CBP73117
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CBP73117
I. Introduction

Cell Line Name:

TEL(ETV6)-JAK2/BaF3

Gene Synonyms:

JKK2

Host Cell:

Ba/F3

Stability: 16 passages

Application:

This kit is useful for screening for small molecules displacing ATP from the JH2 domain of JAK2.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

 
II.Background

JAK2, Janus kinase 2, is a non-receptor protein tyrosine kinase that binds cytokine receptors to activate the interferon-alpha/beta/gamma pathway and is a member of the JAK/STAT signaling pathway (PMID: 15575979, PMID: 30092288). JAK2 mutations are observed in a variety of tumor types, including myeloproliferative neoplasms (PMID: 30074114), lymphoma (PMID: 29984752), leukemia (PMID: 29979407), and cervical cancer (PMID: 30003068). 

 
III. Representative Data

1.WB of BA/F3/TEL(ETV6)-JAK2

 

 

2. Anti-proliferation assay

 

Figure 2. CTG Proliferation Assay of BaF3 TEL-JAK2 (C1).

 

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