• 名称: EOMA(小鼠血管内皮瘤细胞)
  • 货号: CBP61138
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CBP61138
I. General information 
Synonyms: EOMA
Background: The EOMA cell line was originally derived in 1980 from a mixed hemangioendothelioma arising in an adult mouse.
Species: Mus musculus, mouse
Tissue: tumor
Disease: hemangioendothelioma
Gender: adult
Morphology: endothelial
Growth Mode: adherent
Doubling Time: N/A
DNA Profile: N/A
Cobioer’s Cell Line Authentication Service
Culture Medium: DMEM+10%FBS
We strongly suggest to purchase the complete medium from Cobioer.
Cryopreservation medium: 90%FBS+10%DMSO
Antigen Expression: CD31 +
vascular addressin +
CD45 (Ly5-T200) +
Receptor Expression: acetylated low density liproprotein
Ref
Oncogene: N/A
Genes Expressed: angiotensin converting enzyme (ACE)
thrombospondin
cathepsin L
endostatin
interleukin-6 (interleukin 6, IL-6)
Cellular Products: angiotensin converting enzyme (ACE)
thrombospondin
cathepsin L
endostatin
interleukin-6 (interleukin 6, IL-6)
Tumor Formation: Yes, in syngeneic mice
Comments: The cells synthesize angiotensin-converting enzyme, express surface receptors for acetylated low density lipoprotein, produce thrombospondin and show intracellular staining with an antibody to von Willebrand factor.
Cathepsin L is secreted by EOMA cells and is responsible for the generation of endostatin L.
Although constitutive cytokine gene expression exists in EOMA cells, the level of IL-6 mRNA is prominently elevated by incubation with Liposome encapsulated hemoglobin (LEH).
The cells constitutively express the vascular addressin identified by antibody MECA-99.
EOMA cells exhibit characteristic endothelial cell properties, such as rearrangement into tubelike structures on Matrigel and retention of cobblestone morphology at confluence. They behave in vitro in a manner similar to microvascular endothelial cells.
For more information, please contact Cobioer (4008-750-250).

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