• 名称: LS513(人盲肠癌细胞)
  • 货号: CBP61154
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CBP61154
I. General information 
Synonyms: LS513
Background: LS513 is a colorectal carcinoma cell line isolated in 1985 from a primary tumor biopsy from a 63 year old Caucasian male patient diagnosed with a Dukes' C mucin secreting cecal tumor located at the Bauhin valve.
Species: Homo sapiens, human
Tissue: cecum
Disease: Dukes' type C,colorectal carcinoma
Gender: male, 63 years, Caucasian
Morphology: epithelial
Growth Mode: adherent
Doubling Time: 25 hrs
DNA Profile: Amelogenin: X,Y
CSF1PO: 10,13
D13S317: 9,10
D16S539: 12,13
D5S818: 9,11
D7S820: 8,11
THO1: 8
TPOX: 8
vWA: 16,17
Cobioer’s Cell Line Authentication Service
Culture Medium: RPMI-1640+10%FBS
We strongly suggest to purchase the complete medium from Cobioer.
Cryopreservation medium: 90%FBS+10%DMSO
Antigen Expression: carcinoembryonic antigen (CEA); ICAM-1; HLA class I positive
Receptor Expression: N/A
Karyotype N/A
Virus Susceptibility Vesicular stomatitis, Orsay (Indiana)
Vesicular stomatitis, Glasgow (Indiana)
Human poliovirus 1 
Oncogene: p53 + (wild type)
Genes Expressed: transforming growth factor beta 1 (TGF beta-1, 83 pg per 106 cells per 24 hours)
Cellular Products: transforming growth factor beta 1 (TGF beta-1, 83 pg per 10 exp6 cells per 24 hours)
Tumor Formation: Yes, forms tumors in nude mice
Comments: LS513 is a colorectal carcinoma cell line isolated in 1985 from a primary tumor biopsy from a 63 year old Caucasian male patient diagnosed with a Dukes' C mucin secreting cecal tumor located at the Bauhin valve.
Approximately 50% of LS513 cells express surface carcinoembryonic antigen (CEA).
LS513 cells express the major histocompatibility (MHC) class I antigens HLA and beta 2 microglobulin.
MHC class II antigens (HLA-DR, DQ, and DP were not detected).
TGF beta-1 is inhibitory for proliferation of LS513 cells, whereas TGF beta-2 has no effect on the growth of these cells.
LS513 cells are 100-fold less sensitive to TGF beta-1 than the LS1034 (ATCC CRL-2158) cell line.
LS513 cells are multidrug resistant (MDR) and are tumorigenic in nude mice.
Colony forming efficiency was 30% in methylcellulose.
For more information, please contact Cobioer (4008-750-250).

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