• 名称: EGFR V769_D770insASV/BaF3
  • 货号: CBP73176
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CBP73176
I. Introduction

Cell Line Name:

EGFR V769_D770insASV/BaF3

Gene Synonyms:

ERBB, mENA, ERBB1, HER1 

Host Cell:

Ba/F3

Stability: 16 passages

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

 
II.Background

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR V769_D770insASV results in the insertion of three amino acids in the protein kinase domain of the Egfr protein between amino acids 769 and 770 (UniProt.org). V769_D770insASV has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions.

 
III. Representative Data

1.WB of EGFR expression

2. Sanger Sequencing of EGFR V769_D770insASV

 

3. Anti-proliferation assay

Figure 3 . Anti-proliferation assay of three reference compounds on the EGFR V769_D770insASV/BaF3 Stable Cell Line.

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