• 名称: EGFR D770_N771insG/BaF3
  • 货号: CBP73178
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CBP73178
I. Introduction

Cell Line Name:

EGFR D770_N771insG/BaF3

Gene Synonyms:

ERBB, mENA, ERBB1, HER1 

Host Cell:

Ba/F3

Stability: 16 passages

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

 
II.Background

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity.EGFR D770_N771insG results in the insertion of a glycine (G) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insG has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions.

 
III. Representative Data

1. Anti-proliferation assay

 

 

Figure . Anti-proliferation assay of three reference compounds on the EGFR D770_N771insG/BaF3 table Cell Line

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