• 名称: EGFR S768_V769delinsIL(S768I&V769L)/BaF3
  • 货号: CBP73181
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CBP73181
I. Introduction

Cell Line Name:

EGFR S768_V769delinsIL(S768I&V769L)/BaF3

Gene Synonyms:

ERBB, mENA, ERBB1, HER1 

Host Cell:

Ba/F3

Stability: 16 passages

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

 
II.Background

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR S768_V769delinsIL results in a deletion of two amino acids in the protein kinase domain of the Egfr protein from aa 768 to aa 769, combined with the insertion of an isoleucine (I) and a leucine (L) at the same site (UniProt.org). S768_V769delinsIL has been identified in the scientific literature (PMID: 17045698, PMID: 27304188), but has not been biochemically characterized and therefore, its effect on Egfr protein function is unknown (PubMed, Jul 2019).

 
III. Representative Data

1. Anti-proliferation assay

 

Figure . Anti-proliferation assay of three reference compounds on the EGFR S768_V769delinsIL(S768I&V769L)/BaF3 Stable Cell Line

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