• 名称: EGFR A763_Y764insFQEA/BaF3
  • 货号: CBP73182
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CBP73182
I. Introduction

Cell Line Name:

EGFR A763_Y764insFQEA/BaF3

Gene Synonyms:

ERBB, mENA, ERBB1, HER1 

Host Cell:

Ba/F3

Stability: 16 passages

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

 
II.Background

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR A763_Y764insFQEA results in the insertion of four amino acids in the C-helix region of the Egfr protein between amino acids 763 and 764 (PMID: 24353160). A763_Y764insFQEA confers a gain of function to Egfr, as indicated by increased kinase activity and is transforming in cell culture (PMID: 24353160, PMID: 29533785).

 
III. Representative Data

1. WB of EGFR A763_Y764insFQEA/BaF3

2.Sanger of EGFR A763_Y764insFQEA/BaF3

 

3. Anti-proliferation assay

 

Figure 3. CTG Proliferation Assay of BaF3 EGFR A763_ Y764insFQEA (C21).

 

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