• 名称: MV-4-11(人急性单核细胞白血病细胞)
  • 货号: CBP60522
  • 浏览次数: 92
  • 已销售数量:0件
  • 评论信息
  • 购买数量:  购买数量不能低于最少订购数量!

购买 询价 收藏 QQ交流 好友推荐

CBP60522
I. General information 
Synonyms: MV-4-11
Background: The MV4-11 cell line was established by Rovera and associates from the blast cells of a 10-year-old male with biphenotypic B-myelomonocytic leukemia. The growth factor, granulocyte/macrophage colony-stimulating factor (GM-CSF), was required to establish this cell line and growth factors are necessary for its continuous proliferation in chemically defined medium [PubMed: 3496132].
Species: Homo sapiens, human
Tissue: peripheral blood
Disease: biphenotypic B myelomonocytic leukemia
Gender: male,10 years
Morphology: lymphoblast
Growth Mode: suspension
DNA Profile: Amelogenin: X,Y
CSF1PO: 10,12
D13S317: 13
D16S539: 11,12
D5S818: 11,12
D7S820: 8,9
THO1: 8,9.3
TPOX: 8,11
vWA: 14,15
Cobioer’s Cell Line Authentication Service
Culture Medium: IMDM+10%FBS
We strongly suggest to purchase the complete medium from Cobioer.
Cryopreservation medium: 90%FBS+10%DMSO
Antigen Expression: CD4; Homo sapiens. CD10; Homo sapiens.  CD15, human; Homo sapiens .  CD4 (40-96%); CD10 (4-11%); CD15 (96-99%)
Genes Expressed: CD4; Homo sapiens, CD10; Homo sapiens, CD15, human; Homo sapiens, CD4 (40-96%); CD10 (4-11%); CD15 (96-99%)
Comments: This line can be propagated in medium supplemented with 10% FBS without the addition of growth factors. IL-3 can independently support the long-term growth of this cell line, but IL-3 antagonized the proliferation of MV4-11 cells in the presence of GM-CSF when both factors were used at very low concentrations. Granulocyte colony stimulating factor (G-CSF) synergized with GM-CSF in inducing proliferation of MV4-11 cells; G-CSF alone causes a transient stimulation of the cell line.
This line was formerly designated ATCC HTB-189.Over 96% of these cells are positive by indirect immunofluorescence for the myelomonocytic antigen CD15, 40-96% are positive for the monocytic antigen CD4, and 4-11% are positive for CD10 [PubMed: 3500218].
For more information, please contact Cobioer (4008-750-250).
Cell Line Overview Mutation Copy Number Variation
Gene Expression RNAi(siRNA/shRNA/sgRNA...) Compound Sensitivity Profile

科佰生物免费提供各类科研数据,请联系我们4008-750-250索取,暂时仅对会员开放。

如下仅展示案例细胞A549数据:

 

Cell Line Overview: Download

Synonyms:

A 549; A549; NCI-A549; A549/ATCC; A549 ATCC; hA549

Background:

This line was initiated in 1972 by D.J. Giard, et al. through explant culture of lung carcinomatous tissue from a 58-year-old Caucasian male. Cells were described to induce tumors in athmyic mice and to synthesize lecithin.

Species:

Homo sapiens, human

Tissue:

Lung

Disease:

Carcinoma

Gender:

Male, 58 years adult, Caucasian

Morphology:

Epithelial cells, growing adherently as monolayer

Growth Mode:

Adherent

Doubling Time:

24~40hrs

DNA Profile:

Amelogenin: X,Y
CSF1PO: 10,12
D13S317: 11
D16S539: 11,12
D5S818: 11
D7S820: 8,11
THO1: 8,9.3
TPOX: 8,11

vWA: 14
Cobioer’s Cell Line Authentication Service

Culture Medium:

F-12K+10%FBS
We strongly suggest to purchase the complete medium from Cobioer.

Cryopreservation medium:

90% Complete Medium+10%DMSO

Photo:

 

 

Mutation: Download
Gene Name(s) Gene Transcript AA Syntax CDS Syntax Mutation Type
AATK ENSG00000181409 ENST00000326724 p.E1219Q c.3655G>C Substitution - Missense
ABCA9 ENSG00000154258 ENST00000340001 p.M1I c.3G>T Substitution - Missense
ABCB1 ENSG00000085563 ENST00000265724 p.Y1267C c.3800A>G Substitution - Missense
ABI3BP ENSG00000154175 ENST00000471714 p.R104Q c.311G>A Substitution - Missense
ABI3BP ENSG00000154175 ENST00000284322 p.R104Q c.311G>A Substitution - Missense
ADH1A ENSG00000187758 ENST00000209668 p.I209V c.625A>G Substitution - Missense
AGTR1 ENSG00000144891 ENST00000349243 p.H132N c.394C>A Substitution - Missense

 

Copy Number Variation: Downlonad
Ensembl Gene Gene Name(s) Copy Number Signal Chromosome
ENSG00000237269 RBMY2TP 0 loss Y
ENSG00000227949 CYCSP46 0 loss Y
ENSG00000234803 FAM197Y2 0 loss Y
ENSG00000230066 FAM197Y3 0 loss Y
ENSG00000237802 FAM197Y6 0 loss Y
ENSG00000228383 FAM197Y7 0 loss Y
ENSG00000233699 TTTY18 0 loss Y
ENSG00000238073 RBMY2HP 0 loss Y

 

Gene Expression: Download
Gene Relative level of mRNA Gene Relative level of mRNA
NOC2L -1.66 SKI -0.75
KLHL17 0.15 MORN1 -0.43
PLEKHN1 0.51 RER1 -0.76
C1orf170 1.12 PEX10 -0.43
HES4 -0.22 PLCH2 0.34
ISG15 -3.09 PANK4 -1.64
AGRN 2.48 HES5 -1.87
RNF223 -1.74 TNFRSF14 -1.37

 

RNAi(siRNA/shRNA/sgRNA...):
Design according to the gene, please contact us 4008-750-250.

 

Compound Sensitivity Profile:Download
Drug Name  Targets  Z Score
Tanespimycin HSP90 -2.656303
Selumetinib MEK1, MEK2 -2.057352
NU7441 DNAPK -1.983103
KU-55933 ATM -1.962478
Refametinib MEK1, MEK2 -1.742238
TW 37 BCL2, BCL-XL, MCL1 -1.739538
AZD8055 MTORC1, MTORC2 -1.667451

关键词: