• 名称: HCC1569(人乳腺癌细胞)
  • 货号: CBP60372
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CBP60372
I. General information 
Synonyms: HCC1569
Background: The cell line is derived from an older patient with a germline mutation in the FHIT gene. The FHIT gene is located at 3p14.2 and the mutation is a transversion at nucleotide 651 (G to T).The patient's daughter carries the same gene mutation.
This cell line was initiated on 3/8/95 and took 19 months to establish.
Species: Homo sapiens, human
Tissue: mammary gland; breast
Disease: TNM stage IV, grade 3, primary metaplastic carcinoma
Gender: female,70 years, Black
Morphology: epithelial
Growth Mode: mixed adherent-suspension
Culture Medium: RPMI-1640+10%FBS
We strongly suggest to purchase the complete medium from Cobioer.
Cryopreservation medium: 90%FBS+10%DMSO
Receptor Expression: estrogen receptor, negative
progesterone receptor, negative
Oncogene: her2/neu +, p53 -
Genes Expressed: Epithelial glycoprotein 2 [EGP2]; cytokeratin 19
Cellular Products: Epithelial glycoprotein 2 [EGP2]; cytokeratin 19
Comments: The patient received prior chemotherapy and had no family history of breast cancer. The tumor was classified as TNM stage IV, grade 3, metaplastic carcinoma with 4 out of 18 lymph node metastasis.
The cells are poorly differentiated.
The cells are positive for expression of Her2-neu and negative for expression of p53.
HCC1569 is positive for the epithelial cell specific marker Epithelial Glycoprotein 2 (EGP2) and for cytokeratin 19.
The cells are negative for expression of estrogen receptor (ER) and for expression of progesterone receptor (PR) by immunohistochemistry, but PR expression was detectable at a low level by cytosolic protein assay.
For more information, please contact Cobioer (4008-750-250).

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