• 名称: CEM/C1(人急性淋巴细胞白血病细胞)
  • 货号: CBP60711
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CBP60711
I. General information 
Synonyms: CEM/C1
Background: CEM/C1 is a camptothecin (CPT) resistant derivative of the human T cell leukemia cell line CCRF-CEM (see ATCC CCL-119). The cell line was selected and subcloned in 1991 for resistance to CPT.
Species: Homo sapiens, human
Tissue: peripheral blood
Disease: acute lymphoblastic leukemia
Gender: Caucasian,Female,4 years
Morphology: lymphoblast
Growth Mode: suspension
Doubling Time: 26 hrs
DNA Profile: Cobioer’s Cell Line Authentication Service
Culture Medium: RPMI-1640 +10%FBS
We strongly suggest to purchase the complete medium from Cobioer.
Cryopreservation medium: 90%FBS+10%DMSO
Tumor Formation: Yes, in nude mice,(The cells form serially transplantable intercranial and subcutaneous tumors.)
Comments: This cell line exhibits cross resistance to both the water soluble (topotecan) and water insoluble (9-amino-CPT and 10,11-methylenedioxy-CPT) analogs of CPT.
CEM/C1 cells are approximately 31 fold less sensitive to CPT than the parental CEM cells.   CEM/C1 cells display atypical multidrug resistance (MDR) and altered topoisomerase I catalytic activity.
Resistance to CPT is stable for up to six months.
For more information, please contact Cobioer (4008-750-250).

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