|I. General information|
|Background:||This cell line was initiated from a primary ductal carcinoma on October 13, 1995, and took 11.5 months to establish|
|Species:||Homo sapiens, human|
|Tissue:||mammary gland; breast/duct|
|Disease:||TNM stage IIB, grade 3,primary ductal carcinoma|
|Gender:||female, 23 years adult, Caucasian|
|Growth Mode:||adherent, The line grows as large epithelial cells with a tendency to float at high cell densities|
|DNA Profile:||Amelogenin: X
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|Receptor Expression:||estrogen receptor, negative
progesterone receptor, negative
|Oncogene:||BRCA1 (mutated, insertion C at nucleotide 5382), her2/neu -, p53 -|
|Genes Expressed:||Epithelial glycoprotein 2 (EGP2)
|Cellular Products:||Epithelial glycoprotein 2 (EGP2)
|Comments:||The tumor was classified as TNM Stage IIB, grade 3
BRCA1 analysis revealed that the cell line is homozygous for the BRCA1 5382C mutation, whereas the lymphoblastoid cell line derived from the same patient is heterozygous for the same mutation
This mutation was present in two other family members; an identical sister also developed breast cancer
The cell line has an acquired mutation of TP53 with wild-type allele loss; an acquired homozygous deletion of the PTEN gene, and loss of heterozygosity at multiple loci known to be involved in the pathogenesis of breast cancer
The cells are negative for expression of Her2-neu and for expression of p53.
HCC1937 is positive for the epithelial cell specific marker Epithelial Glycoprotein 2 (EGP2) and for cytokeratin 19
The cells are negative for expression of estrogen receptor (ER) and progesterone receptor (PR)
An EBV transformed lymphoblastoid cell line (HCC1937BL) from the same patient is available as ATCC CRL-2337
For more information, please contact Cobioer (4008-750-250).