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KASUMI-1(人急性粒细胞白血病细胞)

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KASUMI-1(人急性粒细胞白血病细胞)

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产品编号
CBP60524
货号:
CBP60524
品牌:
Cobioer
规格:
T-25 Flask
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CBP60524
I. General information 
Synonyms: KASUMI-1
Background: The cell line was established from the peripheral blood of an acute myeloid leukemia (AML) patient.
Species: Homo sapiens, human
Disease: Acute myeloblastic leukemia
Gender: Male
Morphology: myeloblast
Growth Mode: suspension
DNA Profile: D5S818: 9,11
D13S317: 11,13
D7S820: 8,11
D16S539: 9,12
vWA: 14
THO1: 6,9
Amelogenin: X
TPOX: 8,9
CSF1PO: 10,12
Cobioer’s Cell Line Authentication Service
Culture Medium: RPMI1640+20%FBS
We strongly suggest to purchase the complete medium from Cobioer.
Cryopreservation medium: 90%FBS+10%DMSO
Comments: This is a leukemic cell line with an 8;21 chromosome translocation. This translocation juxtaposes the AML1 with ETO (or MTG8) gene, giving rise to the fusion gene AML1-ETO (also known as AML1-MTG or RUNX1-CBF2T1), hence the cells produce chimeric AML1-ETO protein. This protein down-regulates CEBPA mRNA, protein and DNA binding activity, which is crucial for the differentiation of granulocytes.The cells are positive for myeloperoxidase showing a morphology of myeloid maturation.
In proliferation assay the cells in culture showed response to interleukin-3 (IL-3), IL-6, granulocyte colony-stimulating factor (G-CSF), and granulocytemacrophage CSF (GM-CSF), but not to IL-1 or IL-5.
Neither granulocytic nor eosinophilic maturation was observed in the in vitro liquid culture by the addition of dimethyl sulfoxide, G-CSF, or IL-5, respectively. Induction of macrophagelike cells was seen by the addition of phorbol ester. Proliferation is inhibited by 1,25S-(OH)2-16,23-diene-26-F3-10-nor D3.
For more information, please contact Cobioer (4008-750-250).
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