|I. General information|
|Background:||MS1 is a pancreatic islet endothelial cell line established in 1994.
Primary islet endothelial cells were transduced with a temperature sensitive SV40 large T antigen (tsA-58-3) constructed and screened for resistance to G418.
Resistant colonies were isolated in cloning rings and screened for uptake of diI-Ac-LDL.
|Species:||Mus musculus, mouse|
|Tissue:||pancreas/islet of Langerhans; endothelium|
We strongly suggest to purchase the complete medium from Cobioer.
|Receptor Expression:||vascular endothelial growth factor (VEGF), expressed|
|Cellular Products:||tissue inhibitor of bioreactive matrix metalloproteinase (high levels)|
|Comments:||The line retains many properties of endothelial cells including uptake of acetylated LDL and expression of both Factor VIII related antigen and VEGF receptor.
The expression of high levels of the tissue inhibitor of bioreactive matrix metalloproteinase makes the behavior of this cell line more like that of normal macrophages from some commonly used strains of mice.
For more information, please contact Cobioer (4008-750-250).