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科研细胞
药靶细胞
标准品
NPY4R/Ga16/CHO
| CBP71328 | |
| I. Background | |
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NPY4R (Neuropeptide Y Receptor Y4) is a Protein Coding gene. Diseases associated with NPY4R include Alzheimer Disease and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide YY receptor activity. |
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| II. Introduction | |
| Host Cell: |
HEK293 |
| Expressed gene: | GenBank accession number NM_000647.3; no expressed tags |
| Stability: | 20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): |
C-C chemokine receptor type 2, CCR2 |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+400ug/ml G418 |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): |
Functional assay for NPY4R receptor |
| Transducer: | Gi |
| Ⅲ. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| Ⅳ.Representative Data | |
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Concentration-dependent stimulation of intracellular calcium mobilization by MCP-1 in CCR2/Ga16/HEK293 and HEK293 cells.
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Figure 1. MCP-1-induced concentration-dependent stimulation of intracellular calcium mobilization in CCR2/Ga16/HEK293 and HEK293 cells. The cells were loaded with Calcium-4 prior to stimulation with an CCR2 receptor agonist, MCP-1. The intracellular calcium change was measured by FlexStation. |
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