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EGFR V769_D770insASV/BaF3

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产品编号
CBP73176
货号:
CBP73176
品牌:
Cobioer
规格:
T-25 Flask
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CBP73176
I. Introduction

Cell Line Name:

EGFR V769_D770insASV/BaF3

Gene Synonyms:

ERBB, mENA, ERBB1, HER1 

Host Cell:

Ba/F3

Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

 
II.Background

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR V769_D770insASV results in the insertion of three amino acids in the protein kinase domain of the Egfr protein between amino acids 769 and 770 (UniProt.org). V769_D770insASV has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions.

 
III. Representative Data

1.WB of EGFR expression

2. Sanger Sequencing of EGFR V769_D770insASV

3. Anti-proliferation assay

Figure 3 . Anti-proliferation assay of three reference compounds on the EGFR V769_D770insASV/BaF3 Stable Cell Line.

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  • Manual download:CBP73176 EGFR V769_D770insASV BaF3.pdf

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