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科研细胞
药靶细胞
标准品
EGFR S768_V769delinsIL(S768I&V769L)/BaF3
| CBP73181 | |
| I. Introduction | |
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Cell Line Name： |
EGFR S768_V769delinsIL(S768I&V769L)/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
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Freeze Medium: |
90% FBS+10% DMSO
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Complete Culture Medium: |
RPMI-1640+10%FBS+2ug/ml puromycin
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Mycoplasma Status: |
Negative |
| II.Background | |
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EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR S768_V769delinsIL results in a deletion of two amino acids in the protein kinase domain of the Egfr protein from aa 768 to aa 769, combined with the insertion of an isoleucine (I) and a leucine (L) at the same site (UniProt.org). S768_V769delinsIL has been identified in the scientific literature (PMID: 17045698, PMID: 27304188), but has not been biochemically characterized and therefore, its effect on Egfr protein function is unknown (PubMed, Jul 2019). |
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| III. Representative Data | |
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1. WB of EGFR S768_V769delinsIL(S768I&V769L)/BaF3
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2. Anti-proliferation assay |
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相关文件
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Manual download：CBP73181 EGFR S768_V769delinsIL(S768I&V769L) BaF3.pdf
大小：2022-08-02
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