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科研细胞

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Hela-DPP4 cell line

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产品编号
CBPC0004
货号:
CBPC0004
品牌:
Cobioer
规格:
1 vial
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CBPC0004
I. Background
Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides.
 
II. Description

DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

 
III. Introduction
Host Cell: Hela
Expressed gene: DPP4
Stability: 32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): DPP4
Freeze Medium: 90% FBS+10% DMSO
Culture Medium:

DMEM+10%FBS+2ug/ml puromycin

Storage: Liquid nitrogen
 
IV. Description of Host Cell Line
Organism: Homo sapiens, human
Tissue:

Cervix

Disease:

Adenocarcinoma

Morphology: Epithelial-like
Growth Properties: Adherent
 
Ⅴ. Representative Data
 

Figure 1.Recombinant Hela cell constitutively expressing human DPP4.

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