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hIL15 Effector Reporter Cell

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hIL15 Effector Reporter Cell

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产品编号
CBP74109
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CBP74109
品牌:
Cobioer
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T-25 Flask
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CBP74109
I. Background
IL-15 has been shown to be produced by human fetal astrocytes and microglial cells in response to IL-1beta, IFN-gamma, or TNF- alpha and may thus play a role in T-cell mediated immune responses in the human central nervous system. IL-15 stimulates proliferation of the established T-cell line CTLL-2, CD8(+) memory T- cells require IL-15 for proliferation. IL-15 is also able to induce generation of cytolytic cells and LAK cells activity in vitro. IL-15 appears to function as a specific maturation factor for NK-cells and can mimic the bone marrow microenvironment in vitro, which is required for NK- cells to acquire lytic functions. IL-15 induces proliferation of mast cells in the absence of functional IL-2 receptor components and utilizes a receptor of 60-65 kDa that is distinct from known components of T-cell IL-15 receptors. The IL-15 receptor on mast cells recruits JAK2 and STAT5, instead of JAK1, JAK3, and STAT3 and STAT5 that are activated in T-cells. The alpha subunit of the IL-15 receptor (IL-15RA) is structurally related to the alpha subunit of the IL-2 receptor and confers high affinity binding of IL-15 to its receptor. IL-15 binds to the beta and gamma chains of the IL2 receptor, which are known to be required for ligand internalization and signal transduction.
 
II. Introduction
Expressed gene: IL15R
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): IL15, AI503618, IL-15, interleukin 15, IL15, Il15
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: RPMI-1640+10%FBS+10ng/ml IL-3+600ug/ml hygromycin+2ug/ml puromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
III. Representative Data

Figure 1. Dose Response of Recombinant Human IL15 in Human IL15 Effector Reporter Cells,the EC50 was 1.2ng/ml.

 
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  • Manual download:CBP74109 hIL15 Effector Reporter Cell.pdf

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