|HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry.|
Recombinant CHO stably expressing human HVEM (TNF receptor superfamily member 14; TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR; GenBank Accession #NM_003820).
|Stability:||32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.)|
|Synonym(s):||HVEM, TNFRSF14, CD270, HVEA, TR2, LIGHTR|
|Freeze Medium:||90% FBS+10% DMSO|
|Application(s):||HVEM binding molecule (such as anti-HVEM antibody) screening and profiling in a cellular context|
|IV. Description of Host Cell Line|
|Organism:||Cricetulus griseus, hamster, Chinese|
|Ⅴ. Representative Data|
Figure 1. Recombinant CHO stably expressing human HVEM (TNF receptor superfamily member 14; TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR; GenBank Accession #NM_003820).