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HVEM/CHO

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产品编号
CBP74037
货号:
CBP74037
品牌:
Cobioer
规格:
T-25 Flask
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CBP74037
I. Background
HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry.
 
II. Description

Recombinant CHO stably expressing human HVEM (TNF receptor superfamily member 14; TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR; GenBank Accession #NM_003820).

 
III. Introduction
Host Cell: CHO
Expressed gene: HVEM
Stability: 32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): HVEM, TNFRSF14, CD270, HVEA, TR2, LIGHTR
Freeze Medium: 90% FBS+10% DMSO
Culture Medium:

F12k+10%FBS+400ug/ml zeocine

Application(s): HVEM binding molecule (such as anti-HVEM antibody) screening and profiling in a cellular context
Storage: Liquid nitrogen
 
IV. Description of Host Cell Line
Organism: Cricetulus griseus, hamster, Chinese
Tissue: Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent
 
Ⅴ. Representative Data

Figure 1. Recombinant CHO stably expressing human HVEM (TNF receptor superfamily member 14; TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR; GenBank Accession #NM_003820).

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