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HVEM/TCR Activator/CHO

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产品编号
CBP74082
货号:
CBP74082
品牌:
Cobioer
规格:
T-25 Flask
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CBP74082
I. Background
HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry.
 
II. Introduction
Expressed gene: HVEM
Stability: 32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): HVEM
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: F12K+10%FBS+600ug/ml hygromycin+2ug/ml puromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
 
III. Representative Data

Figure 1. Recombinant HVEM/TCR Activator/CHO constitutively expressing HVEM.

Figure 2. Dose Response of BTLA Blocking Antibody in BTLA Effector Reporter Cells (Clone 1) With HVEM /TCR Activator - CHO Cells.

Figure 3. Dose Response of BTLA Blocking Antibody in BTLA Effector Reporter Cells (Clone 1) With HVEM/TCR Activator - CHO Cells.

 
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  • Manual download:HVEM TCR ActivatorCHO CBP74082.pdf

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    2022-04-27
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