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ICOS Effector Reporter Cell

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产品编号
CBP74063
货号:
CBP74063
品牌:
Cobioer
规格:
T-25 Flask
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CBP74063
I. Background
ICOS is a costimulatory molecule of the CD28 cell surface receptor superfamily that is expressed on activated T-cells. ICOS is involved in T-cell responses upon binding with its ligand, ICOSL (also known as B7-H2, CD275), which is normally expressed on B-cells, dendritic cells and monocytes.
 
II. Description

 ICOS expression confers an activated phenotype and a strong suppressive capacity to intra-tumoral regulatory T-cells. The ICOS/ICOSL pathway is a key target for cancer immunotherapy.

 
III. Introduction
Expressed gene: ICOS
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): T-cell costimulator, CD278
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: RPMI-1640+10%FBS+800ug/ml hygromycin+10ug/ml blasticidin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
 
IV. Representative Data

Figure 1. Dose response of Anti-lCOS Ab in ICOS Effector Reporter Cells(C5).

 
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  • Manual download:CBP74063 ICOS Effector Reporter Cell.pdf

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