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科研细胞

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ICOSL/CHO

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产品编号
CBP74068
货号:
CBP74068
品牌:
Cobioer
规格:
T-25 Flask
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CBP74068
I. Background
ICOSL is the Ligand for the T-cell-specific cell surface receptor ICOS. When engaged by the ICOSL, the ICOS initiates a costimulatory signal for T-cell proliferation and cytokine production. It also induces B-cell proliferation and differentiation into plasma cells. The ICOS/ICOSL is a major regulator of the adaptive immune responses and also plays an important role in mediating local tissue responses to inflammatory conditions.
 
II. Description

Recombinant CHO-K1 cells constitutively expressing human ICOSL (also known as human secreted B7 homolog 2 (B7-H2), CD275, ICOSLG, and B7-related protein (B7RP), GenBank Accession No. NM_001283050.

 
III. Introduction
Host Cell: CHO
Expressed gene: ICOSL
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): B7 homolog 2, CD275, ICOSL, ICOSLG, B7-related protein (B7RP), B7-H2
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: F12k+10%FBS+500ug/ml Hygromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Ligand of ICOS&Binding Assay,FACS
 
IV. Description of Host Cell Line
Organism: Cricetulus griseus, hamster, Chinese
Tissue: Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent
 
Ⅴ. Representative Data

 

Figure 1.Recombinant CHO-cells constitutively expressing human ICOSL.

 

 

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