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IL4 Effector Reporter Cell

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产品编号
CBP74110
货号:
CBP74110
品牌:
Cobioer
规格:
T-25 Flask
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CBP74110
I. Background
Interleukin-4 is produced mainly by a subpopulation of activated T-cells (Th2) that are the biologically most active helper cells for B-cells and that also secrete IL-5 and IL-6. The biological activities of IL-4 are mediated by a specific receptor. The extracellular domain of the IL-4 receptor is related to the receptors for EPO, IL-6, and the beta chain of the IL2 receptor (CD124). Two types of IL-4 receptor (IL-4R) exist: the type 1 receptor is a heterodimer consisting of CD132 and IL-4R-alpha. The type 2 receptor is a heterodimer consisting of IL-4Ralpha and IL-13Ralpha1. IL-4 enhances expression of MHC class 2 antigens on B-cells. It can promote their capacity to respond to other B-cell stimuli and to present antigens for T-cells. Pretreatment of macrophages with IL-4 prevents the production of IL1, TNF-alpha and prostaglandins in response to activation of the cells by bacterial endotoxins or IFN-gamma. IL-4 synergises with EPO and G-CSF in the generation of colonies containing granulocytes or erythroid progenitor cells in a colony formation assay.
 
II. Introduction
Expressed gene: IL4
Stability: 32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): IL4
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: DMEM + 10%FBS+100ug/ml hygromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
 
III. Representative Data

Figure 1. Dose Response of Recombinant Human IL4 in Human IL4 Effector Reporter Cells(C7).

Figure 2. Inhibition of lL-4-induced Reporter Activity by IL-4R Neutralizing Antibody in IL4 Effector Reporter Cells (Clone7).

 
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  • Manual download:IL4 Effector Reporter Cell CBP74110.pdf

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    2022-04-06
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