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LAG3/HEK293

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产品编号
CBP74051
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CBP74051
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Cobioer
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T-25 Flask
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CBP74051
I. Background
Lymphocyte-activation gene 3 (LAG3, CD223) is a cell surface protein that belongs to immunoglobulin (Ig) superfamily. LAG3 is expressed on activated T cells, natural killer cells, B cells, and plasmacytoid dendritic cells. Its main ligand is MHC class II, to which it binds with higher affinity than CD4. It negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1, and has been reported to play a role in Treg suppressive function. A number of LAG3 antibodies are in preclinical development for treatments for cancer and autoimmune disorders. LAG3 may be a better immune checkpoint inhibitor target than CTLA-4 or PD-1 since antibodies to these two checkpoints are only activating effector T cells, and not inhibiting Treg activity where an antagonist LAG3 antibody can both activate effector T cells (by downregulating the LAG3 inhibiting signal) and inhibit induced (i.e. antigen-specific) Treg suppressive activity.
 
II. Description
Recombinant HEK293 stably expressing human LAG3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286).
 
III. Introduction
Host Cell: HEK293
Expressed gene: LAG3
Stability: 32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): LAG3, LAG-3, CD223
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: DMEM +10%FBS+1ug/ml puromycin
Mycoplasma Testing: Negative
Storage: Immediately upon receipt, store in liquid nitrogen.
Application(s): LAG3 binding molecule (such as anti-LAG3 antibody) screening and profiling in a cellular context
 
IV. Description of Host Cell Line
Organism: Homo sapiens, human
Tissue: Embryonic kidney
Disease: Normal
Morphology: Epitheloid cell
Growth Properties: Adherent
 
Ⅴ. Representative Data

Figure 1. Recombinant HEK293 stably expressing human LAG3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286).

 

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