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药靶细胞

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NGS靶向捕获探针

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LIGHT/CHO

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产品编号

CBP74029

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CBP74029

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Cobioer

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T-25 Flask

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CBP74029
I. Background
LIGHT (TNFSF14) is a key component of the communication system that controls the responses of T-Cells. LIGHT activates two cell surface receptors, the Herpesvirus Entry Mediator (HVEM) and the Lymphotoxin-beta Receptor (LTβR). The LIGHT-HVEM axis is an important costimulatory pathway for T cells, it has been shown to activate NF-κB; LIGHT/HVEM pair are co-stimulatory immune checkpoint molecules for cancer immunotherapy, LIGHT expressing cells have been shown to be more potent than the soluble LIGHT for activating HVEM expressed on T cell surface.

II. Description
Recombinant stable clonal CHO cell line constitutively expressing full length human LIGHT protein, also known as TNFSF14, (Genbank #NM_003807). Surface expression is confirmed by flow cytometry.

III. Introduction
Host Cell:	CHO
Expressed gene:	Light
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):	TNFSF14, light cho
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	F12K+10%FBS+300ug/ml hygromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Ligand of HVEM&Binding Assay, FACS

IV. Description of Host Cell Line
Organism:	Cricetulus griseus, hamster, Chinese
Tissue:	Ovary
Disease:	Normal
Morphology:	Epitheloid cell
Growth Properties:	Adherent

Ⅴ. Representative Data

Figure. Recombinant stable clonal CHO cell line constitutively expressing full length human LIGHT protein, also known as TNFSF14, (Genbank #NM_003807). Surface expression is confirmed by flow cytometry.