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OX40/HEK293

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产品编号
CBP74049
货号:
CBP74049
品牌:
Cobioer
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T-25 Flask
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CBP74049
I. Background
OX40 (CD134) is a co-stimulatory receptor expressed on the surface of CD4+ and CD8+ T cells 24 to 48 hours after activation. Binding of OX40 to its ligand, OX40L (CD252), present on dendritic cells, potentiates T cell survival and increases cytokine production. OX40 has been shown to activate NF-κB-mediated memory cell generation through its interaction with adaptor proteins TRAF2 and TRAF5. OX40 has a critical role in the maintenance of an immune response beyond the first few days and onwards to a memory response.
 
II. Description
Recombinant HEK293 stably expressing human OX40 (TNF receptor superfamily member 4, TNFRSF4, ACT35; CD134; IMD16; TXGP1L, GenBank Accession #NM_003327).
 
III. Introduction
Host Cell: HEK293
Expressed gene: OX40
Stability: 32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): TNFRSF4, ACT35, IMD16, TXGP1L, Tumor Necrosis Factor Receptor Superfamily Member 4, TNFRSF4, CD134
Freeze Medium: 90% FBS+10% DMSO
Culture Medium:

DMEM+10%FBS+1ug/ml puromycin

Mycoplasma Testing: Negative
Storage: Immediately upon receipt, store in liquid nitrogen.
Application(s): OX40 binding molecule (such as anti-OX40 antibody) screening and profiling in a cellular context
 
IV. Description of Host Cell Line
Organism: Homo sapiens,human
Tissue: Embryonic kidney
Disease: Normal
Morphology: Epitheloid cell
Growth Properties: Adherent
 
Ⅴ. Representative Data
 

Figure 1.Recombinant HEK293 stably expressing human OX40 (TNF receptor superfamily member 4, TNFRSF4, ACT35; CD134; IMD16; TXGP1L, GenBank Accession #NM_003327).

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