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PDL1/TCR Activator/CHO

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产品编号
CBP74066
货号:
CBP74066
品牌:
Cobioer
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T-25 Flask
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CBP74066
I. Background
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. PD-1 ligands are found on most cancers, and the PD-1:PD-L1/2 interaction inhibits T-cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
 
II. Description

Recombinant CHO-K1 cells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # NM_014143) an engineered T cell receptor (TCR) activator.

 
III. Introduction
Host Cell: CHO-K1
Expressed gene: PD-L1
Stability: 32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: F12K+10%FBS+2ug/ml puromycin+500ug/ml hygromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Screen for activators or inhibitors of PD-1 signaling in a cellular context , screen PD-L1 antibodies for binding affinity • Characterize the biological activity of PD-1 interactions with PD-L1
 
IV. Description of Host Cell Line
Organism: Cricetulus griseus, hamster, Chinese
Tissue: Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent
 
Ⅴ. Representative Data

Figure 1.Recombinant CHO cells constitutively expressing human PD-L1 and an engineered T-cell receptor (TCR) activator.

 

Figure 2. Dose response curve of anti-PD-L1 antibody on PD-1/PD-L1 Blockade Bioassay Model. 

 
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  • Manual download:PDL1 TCR ActivatorCHO CBP74066.pdf

    大小:
    2022-04-06
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