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PVRIG(CD112R) Effector Reporter Cell

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PVRIG(CD112R) Effector Reporter Cell

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产品编号
CBP74120
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CBP74120
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Cobioer
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T-25 Flask
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CBP74120
I. Background

PVRIG (CD112R) is an regulatory protein expressed on T-cells which inhibits immune activation when binding to its counterpart on APCs, PVRL2 (CD112, Nectin-2). Since both PVRL2 and PVR can activate DNAM-1 (CD226), PVRIG works synergistically with and separately from TIGIT. PVRL2 is overexpressed in a variety of tumor types, including breast and ovarian cancers, suggesting that its interaction with PVRIG is a major mechanism of immune suppression in those diseases.

 
II. Description
Human secreted CD112R, also known as Poliovirus Receptor-related Immunoglobulin Domain
containing Protein (PVRIG), GenBank Accession No. NM_024070, a.a. 41-172, with C-terminal Fc-Fusion-Avi
tag, expressed in a HEK293 cell expression system and enzymatically biotin-labeled using AviTag technology. MW = 42 kDa. 
 
III. Introduction
Expressed gene:

PVRIG(CD112R)

Stability: 32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): Poliovirus Receptor-related Immunoglobulin Domain-containing Protein, Transmembrane Protein PVRIG, 79270-1, 79270-2
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: RPMI-1640+10%FBS+800ug/ml hygromycin+1ug/ml puromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
 
IV. Representative Data

Figure 1. Dose Response of PVRIG Blocking Antibody in PVRIG(CD112R) Effector Reporter Cells (Clone 7) With CD112/TCR Activator - CHO Cells.

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  • Manual download:PVRIG(CD112R) Effector Reporter Cell CBP74120.pdf

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    2022-04-21
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