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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
EGFR V769_D770insASV/BaF3
| CBP73176 | |
| I. Introduction | |
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Cell Line Name： |
EGFR V769_D770insASV/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
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Freeze Medium: |
90% FBS+10% DMSO
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Complete Culture Medium: |
RPMI-1640+10%FBS |
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Mycoplasma Status: |
Negative |
| II.Background | |
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EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR V769_D770insASV results in the insertion of three amino acids in the protein kinase domain of the Egfr protein between amino acids 769 and 770 (UniProt.org). V769_D770insASV has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions. |
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| III. Representative Data | |
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1.WB of EGFR expression
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2. Sanger Sequencing of EGFR V769_D770insASV
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3. Anti-proliferation assay
Figure 3 . Anti-proliferation assay of three reference compounds on the EGFR V769_D770insASV/BaF3 Stable Cell Line. |
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