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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
TPM3-NTRK1/BaF3
| CBP73203 | |
| I. Introduction | |
| Cell Line Name： | TPM3-NTRK1/BaF3 |
| Host Cell: | BA/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Application: | Anti-proliferation assay and PD assay |
| Freeze Medium: | 90% FBS+10% DMSO |
| Complete Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
| Mycoplasma Status: | Negative |
| II.Background | |
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NTRK1 rearrangements involve the kinase domain of the NTRK1 gene which includes 17 exons located on chromosome 1q21-22 (Alberti et al. 2003). The frequency of NTRK1 fusions in patients with adenocarcinoma histology is 3.3% of cases (3 out of 91 patients; Vaishnavi et al. 2013). |
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| III. Representative Data | |
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1. WB of TPM3-NTRK1/BaF3 expression
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2. Sanger of TPM3-NTRK1/BaF3
Figure 2. Sanger Sequencing of TPM3-NTRK1/BaF3 |
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3. Anti-proliferation assay
Figure 3. Anti-proliferation assay of two reference compounds on the TPM3-NTRK1/BaF3 Stable Cell Line. |
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