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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
EGFR D770_N771insY/BaF3
| CBP73218 | |
| I. Introduction | |
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Cell Line Name： |
EGFR D770_N771insY/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
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Freeze Medium: |
90% FBS+10% DMSO
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Complete Culture Medium: |
RPMI-1640+10%FBS
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Mycoplasma Status: |
Negative |
| II.Background | |
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EGFR D770_N771insY results in the insertion of a tyrosine (Y) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insY has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions (PMID: 24353160). |
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| III. Representative Data | |
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1. WB of EGFR D770_N771insY/BaF3
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| 2. Anti-proliferation assay | |
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