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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
EGFR D770_N771insY/BaF3
CBP73218 | |
I. Introduction | |
Cell Line Name: | EGFR D770_N771insY/BaF3 |
Host Cell: | Ba/F3 |
Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
II.Background | |
EGFR D770_N771insY results in the insertion of a tyrosine (Y) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insY has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions (PMID: 24353160). |
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III. Representative Data | |
1. WB of EGFR D770_N771insY/BaF3 |
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2. Anti-proliferation assay |

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