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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
EGFR VIII/BaF3
| CBP73226 | |
| I. Introduction | |
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Cell Line Name： |
EGFR VIII/BaF3 |
|
Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Freeze Medium: | 90% FBS+10% DMSO |
|
Complete Culture Medium: |
RPMI-1640+10%FBS
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Mycoplasma Status: |
Negative |
| II.Background | |
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EGFR (HER1), epidermal growth factor receptor, is a tyrosine kinase receptor, which activates RAS/RAF/MEK and PI3K/AKT/mTOR pathways, leading to increased cell proliferation and growth (PMID: 24312144). EGFR activating mutations, amplification, and overexpression are found in a variety of tumors, including non-small cell lung cancer (PMID: 26609494, PMID: 30284706) and colorectal cancer (PMID: 30243897), and the EGFRvIII variant is commonly found in glioblastoma (PMID: 30201736). |
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| III. Representative Data | |
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1. Anti-proliferation assay
Figure . Anti-proliferation assay of three reference compounds on the EGFR VIII/BaF3 Stable Cell Line . |
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