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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
TPM3-NTRK1 [F589L]/BaF3
| CBP73259 | |
| I. Introduction | |
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Cell Line Name： |
TPM3-NTRK1 [F589L]/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Freeze Medium: | 90% FBS+10% DMSO |
| Complete Culture Medium: | RPMI-1640+10%FBS |
| Mycoplasma Status: | Negative |
| II.Background | |
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TPM3, tropomyosin 3, is a member of the tropomyosin family of actin-interacting proteins, which regulates actin function and plays an essential role in embryonic development (PMID: 23904035, PMID: 26240174). TPM3-NTRK1 fusions are recurrent in colorectal cancer (PMID: 24962792, PMID: 30279230) and additional fusions, with multiple gene partners, have been identified in other tumor types, including inflammatory myofibroblastic tumors (PMID: 10934142), anaplastic large cell lymphoma (PMID: 10216106), renal cell carcinoma (PMID: 32102128), and lung cancer (PMID: 25667280). |
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| III. Representative Data | |
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1.TPM3-NTRK1 [F589L]/BaF3
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2. Anti-proliferation assay
Figure . Anti-proliferation assay of three reference compounds on the TPM3-NTRK1 [F589L]/BaF3 Stable Cell Line. |
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