南京科佰生物科技有限公司官方网站欢迎您的光临！
免费咨询热线： 4008-750-250
科研细胞
药靶细胞
标准品
NGS靶向捕获探针
c-Kit W557_K558del-T670I/BaF3
|
CBP73284 |
|
| I. Introduction | |
|
Cell Line Name： |
c-Kit W557_K558del-T670I/BaF3 |
|
Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
|
Application: |
Anti-proliferation assay and PD assay |
|
Freeze Medium: |
90% FBS+10% DMSO |
|
Complete Culture Medium: |
RPMI-1640+10%FBS |
|
Mycoplasma Status: |
Negative |
| II.Background | |
|
KIT W557_K558del results in the deletion of 2 amino acids in the juxtamembrane domain (exon 11) of the Kit protein from amino acids 557 to 558 (PMID: 12918066). W557_K558del results in constitutive activation of Kit and increased Erk phosphorylation, and leads to increased invasiveness and expression of ETV1 in cell culture (PMID: 25239608, PMID: 26936919). |
|
| III. Representative Data | |
|
1. c-Kit W557_K558del-T670I/BaF3
|
|
|
2.Sanger of c-Kit W557_K558del-T670I/BaF3
Figure 2. c-Kit W557_K558del-T670I/BaF3 T670I
Figure 3. c-Kit W557_K558del-T670I/BaF3 W557_K558del |
|
|
3. Anti-proliferation assay
Figure 4. CTG Proliferation Assay of BaF3 C-KIT W557_ K558del/T670I (C8). |
|
|
|
|
扫一扫，关注我们公众号
Copyright ©2021 www.cobioer.com All Rights Reserved. 南京科佰生物科技有限公司版权所有 苏ICP备13038923号