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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
c-Kit K642E-D816A/BaF3
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CBP73294 |
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| I. Introduction | |
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Cell Line Name： |
c-Kit K642E-D816A/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Anti-proliferation assay and PD assay |
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Freeze Medium: |
90% FBS+10% DMSO |
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Complete Culture Medium: |
RPMI-1640+10%FBS |
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Mycoplasma Status: |
Negative |
| II.Background | |
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KIT K642E lies within the tyrosine kinase domain 1 (exon 13) of the Kit protein (PMID: 15990278). K642E results in constitutive phosphorylation of Kit and activation of downstream signaling (PMID: 15990278, PMID: 19802003), as well as transformation of cultured cells (PMID: 11073817). |
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| III. Representative Data | |
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1.Sanger of c-Kit K642E-D816A/BaF3
Figure 1. c-Kit_K642E-D816A/BaF3 K642E
Figure 2. c-Kit K642E-D816A/BaF3 D816A |
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2. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of BaF3 c-KIT K642E/D816A (C5). |
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