科研细胞

科研细胞



药靶细胞

药靶细胞



标准品



NGS靶向捕获探针

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产品编号

.CBP74028

货号:

.CBP74028

品牌:

Cobioer

规格:

T-25 Flask

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产品数据库

CBP74028
I. Background
The nuclear factor of activator T cells (NFAT) family of transcription factors plays an important role in immune response. T cell activation through the T cell synapse results in calcium influx. Increased intracellular calcium levels activate the calcium-sensitive phosphatase, calcineurin, which rapidly dephosphorylates the serine-rich region (SRR) and SP-repeats in the amino termini of NFAT proteins.

II. Description
This results in a conformational change that exposes a nuclear localization signal promoting NFAT nuclear import. In the nucleus, NFAT proteins cooperate with other proteins to bind to DNA.

III. Introduction
Host Cell:	HEK293
Expressed gene:	NFAT-Luciferase
Stability:	32 passages
Synonym(s):	Nuclear factor of activated T cells; T cell
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	DMEM+10% FBS+300 ug/ml hygromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Functional(Report Gene) Assay

IV. Description of Host Cell Line
Organism:	Homo sapiens, human
Tissue:	Embryonic kidney
Disease:	Normal
Morphology:	Epitheloid
Growth Properties:	Adherent

Ⅴ. Representative Data

Figure 1. NFAT Luciferase Reporter - HEK293 Recombinant Cell Line (C8).
Figure 2. NFAT Luciferase Reporter -HEK293 Recombinant Cell Line (C4).