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CD155/TCR Activator/CHO

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CBP74073

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CBP74073

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Cobioer

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T-25 Flask

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CBP74073
I. Background
CD155, or poliovirus receptor (PVR), has recently emerged as a pro-tumorigenic antigen, overexpressed on GBM and contributing to increased GBM migration and aggressiveness. CD155 has also been established as an immunomodulatory receptor, able to both activate NK cells through interactions with CD226 (DNAM-1) and CD96 and inhibit them through interaction with TIGIT.

II. Description
Recombinant CHO-K1 cells constitutively expressing human CD155 (Poliovirus receptor, Nectin-like protein 5, GenBank accession # NM_006505) and an engineered T cell receptor (TCR) activator.

III. Introduction
Host Cell:	CHO
Expressed gene:	CD155
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):	Poliovirus receptor, Nectin-like protein 5, CD155-His
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	F12K+10%FBS+800ug/ml hygromycin+1ug/ml puromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Functional(Report Gene) Assay

IV. Description of Host Cell Line
Organism:	Cricetulus griseus, hamster, Chinese
Tissue:	Ovary
Disease:	Hamster Chinese ovary
Morphology:	Epitheloid cell
Growth Properties:	Adherent

Ⅴ. Representative Data
Figure 1.Recombinant CHO-cells constitutively expressing CD155 and an engineered T cell receptor (TCR) activator.
Figure 2. Dose response of anti-TIGIT neutralizing antibody in TIGIT /NFAT-Reporter Jurkat cell line (C26) with CD155/ TCR activator - CHO.