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HVEM/HEK293

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CBP74047

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CBP74047

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Cobioer

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T-25 Flask

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CBP74047
I. Background
HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Alternately, interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry.

II. Description
Recombinant HEK293 stably expressing human HVEM (Herpesvirus entry mediator; CD270; TNFRSF14; ATAR) GenBank Accession # NM_003820).

III. Introduction
Host Cell:	HEK293
Expressed gene:	HVEM
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):	Immunotherapy, CD270, Herpesvirus entry mediator, HVEM, HEK293, HVEM - HEK293, TNFRSF14, BTLA
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	DMEM+10%FBS+1ug/ml puromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen.
Application(s):	Binding Assay,FACS

IV. Description of Host Cell Line
Organism:	Homo sapiens,human
Tissue:	Embryonic kidney
Disease:	Normal
Morphology:	Epitheloid cell
Growth Properties:	Adherent

Ⅴ. Representative Data

Figure 1.Recombinant HEK293 stably expressing human HVEM (Herpesvirus entry mediator; CD270; TNFRSF14; ATAR) GenBank Accession # NM_003820).