|HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry.|
|Stability:||32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)|
|Synonym(s):||HVEM, TNFRSF14, CD270, HVEA, TR2, LIGHTR|
|Freeze Medium:||90% FBS+10% DMSO|
|Culture Medium:||F12K+10%FBS+600ug/ml hygromycin+2ug/ml puromycin|
|Application(s):||Functional(Report Gene) Assay|
|III. Representative Data|
Figure 1. Recombinant HVEM/TCR Activator/CHO constitutively expressing HVEM.
Figure 2. Dose Response of BTLA Blocking Antibody in BTLA Effector Reporter Cells (Clone 1) With HVEM /TCR Activator - CHO Cells.
Figure 3. Dose Response of BTLA Blocking Antibody in BTLA Effector Reporter Cells (Clone 1) With HVEM/TCR Activator - CHO Cells.
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