科研细胞

科研细胞

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药靶细胞

药靶细胞

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NGS靶向捕获探针

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产品编号

CBP74063

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CBP74063

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Cobioer

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T-25 Flask

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CBP74063
I. Background
ICOS is a costimulatory molecule of the CD28 cell surface receptor superfamily that is expressed on activated T-cells. ICOS is involved in T-cell responses upon binding with its ligand, ICOSL (also known as B7-H2, CD275), which is normally expressed on B-cells, dendritic cells and monocytes.

II. Description
ICOS expression confers an activated phenotype and a strong suppressive capacity to intra-tumoral regulatory T-cells. The ICOS/ICOSL pathway is a key target for cancer immunotherapy.

III. Introduction
Expressed gene:	ICOS
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):	T-cell costimulator, CD278
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	RPMI-1640+10%FBS+800ug/ml hygromycin+10ug/ml blasticidin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Functional(Report Gene) Assay


IV. Representative Data
Figure 1. Dose response of Anti-lCOS Ab in ICOS Effector Reporter Cells(C5).