|ICOSL is the Ligand for the T-cell-specific cell surface receptor ICOS. When engaged by the ICOSL, the ICOS initiates a costimulatory signal for T-cell proliferation and cytokine production. It also induces B-cell proliferation and differentiation into plasma cells. The ICOS/ICOSL is a major regulator of the adaptive immune responses and also plays an important role in mediating local tissue responses to inflammatory conditions.|
Recombinant CHO-K1 cells constitutively expressing human ICOSL (also known as human secreted B7 homolog 2 (B7-H2), CD275, ICOSLG, and B7-related protein (B7RP), GenBank Accession No. NM_001283050.
|Stability:||32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)|
|Synonym(s):||B7 homolog 2, CD275, ICOSL, ICOSLG, B7-related protein (B7RP), B7-H2|
|Freeze Medium:||90% FBS+10% DMSO|
|Culture Medium:||F12k+10%FBS+500ug/ml Hygromycin|
|Application(s):||Ligand of ICOS&Binding Assay,FACS|
|IV. Description of Host Cell Line|
|Organism:||Cricetulus griseus, hamster, Chinese|
|Disease:||Hamster Chinese ovary|
|Ⅴ. Representative Data|
Figure 1.Recombinant CHO-cells constitutively expressing human ICOSL.