南京科佰生物科技有限公司官方网站欢迎您的光临!

免费咨询热线: 4008-750-250

搜索
确认
取消

科研细胞

科研细胞

药靶细胞

药靶细胞

标准品

标准品

NGS靶向捕获探针

NGS靶向捕获探针
浏览量:
0

PDL1/Raji

所属分类
返回列表
1
零售价
0.0
市场价
0.0
浏览量:
0
产品编号
CBP74095
货号:
CBP74095
品牌:
Cobioer
规格:
T-25 Flask
物种:
组织:
数量
-
+
库存:
0
产品描述
参数
产品数据库
CBP74095
I. Background
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
 
II. Description
Recombinant Raji cells expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # NM_014143).
 
III. Introduction
Host Cell: Raji
Expressed gene: PDL1
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: RPMI-1640+10%FBS+200ug/ml hygromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Binding Assay,FACS
 
IV. Description of Host Cell Line
Organism: Human
Tissue: lymphoblast
Disease: Burkitt's lymphoma
Morphology: lymphoblast
Growth Properties: suspension
 
Ⅴ. Representative Data

Figure 1.RecombinantRajicells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession #NM_014143).

Figure 2. Blocking of PD-L1 induced PD-1/SHP2 Reporter Cells (C17) Activity by PD-L1 Blocking Ab with PD-L1 Target cells (suspended).

Figure 3. Blocking of PD-1 induced PD-1/SHP2 Reporter Cells (C17) Activity by PD-1 Blocking Ab with PD-L1 Target cells (suspended).

 

未找到相应参数组,请于后台属性模板中添加
上一个
下一个

相关文件

上一页
1

相关产品推荐

暂时没有内容信息显示
请先在网站后台添加数据记录。

联系我们

地址:南京市栖霞区纬地路9号/实验室地址:上海市浦东新区广丹路222号 

邮箱: sales@cobioer.com (销售部) tech@cobioer.com (技术部)

 COBIOER

扫一扫,关注我们公众号

Copyright ©2021 www.cobioer.com All Rights Reserved. 南京科佰生物科技有限公司版权所有 苏ICP备13038923号