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PVRIG(CD112R) Effector Reporter Cell

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CBP74120

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CBP74120

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Cobioer

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T-25 Flask

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CBP74120
I. Background
PVRIG (CD112R) is an regulatory protein expressed on T-cells which inhibits immune activation when binding to its counterpart on APCs, PVRL2 (CD112, Nectin-2). Since both PVRL2 and PVR can activate DNAM-1 (CD226), PVRIG works synergistically with and separately from TIGIT. PVRL2 is overexpressed in a variety of tumor types, including breast and ovarian cancers, suggesting that its interaction with PVRIG is a major mechanism of immune suppression in those diseases.

II. Description
Human secreted CD112R, also known as Poliovirus Receptor-related Immunoglobulin Domain containing Protein (PVRIG), GenBank Accession No. NM_024070, a.a. 41-172, with C-terminal Fc-Fusion-Avi tag, expressed in a HEK293 cell expression system and enzymatically biotin-labeled using AviTag technology. MW = 42 kDa.

III. Introduction
Expressed gene:	PVRIG(CD112R)
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):	Poliovirus Receptor-related Immunoglobulin Domain-containing Protein, Transmembrane Protein PVRIG, 79270-1, 79270-2
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	RPMI-1640+10%FBS+800ug/ml hygromycin+1ug/ml puromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Functional(Report Gene) Assay

IV. Representative Data

Figure 1. Dose Response of PVRIG Blocking Antibody in PVRIG(CD112R) Effector Reporter Cells (Clone 7) With CD112/TCR Activator - CHO Cells.