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TLR7/NFkB-Luc/HEK293

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CBP74090

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CBP74090

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Cobioer

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T-25 Flask

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CBP74090
I. Background
TLR7, toll like receptor 7, is an endosomal receptor that recognizes single-stranded RNA and functions in activation of the inflammatory response (PMID: 28620298, PMID: 28374903). Overexpression of Tlr7 has been demonstrated in pancreatic cancer (PMID: 26134824), esophageal squamous cell carcinoma, and gastroesophageal junction adenocarcinoma (PMID: 29968427, PMID: 21990957).

II. Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression.

III. Introduction
Host Cell:	HEK293
Expressed gene:	TLR7、NFkB-Luc
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	MEM+10% Foetal Bovine Serum (FBS)+ 1% Non Essential Amino Acids (NEAA) + 1mM Sodium Pyruvate (NaP) +100ug/ml hygromycin+1ug/ml puromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Functional(Report Gene) Assay

IV. Description of Host Cell Line
Organism:	Human
Tissue:	Embryonic kidney
Disease:	Normal
Morphology:	Epitheloid cell
Growth Properties:	Adherent

Ⅴ. Representative Data

Figure 1. TLR7/NF-KB Reporter - HEK293 Recombinant Cell Line(C4).