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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
TP53 p.R273C Reference Standard
CBP10137
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Format | Genomic DNA |
Description | TP53 R273C is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). R273C results in decreased activation of wild-type Tp53 target genes, as well as aberrant activation of gene expression, and increased cell proliferation and migration in culture (PMID: 23264849, PMID: 23612969, PMID: 16861262). |
Technical Data | |
DNA Change: | c.817C>T |
AA Change | p.R273C |
Mutation type | Substitution - Missense |
Zygosity | Homozygous |
Allelic Frequency | 100% |
Transcript | ENST00000269305 |
Cosmic ID | COSM10659 |
Chr position(GRCh37) | chr17:7577121 |
Buffer: | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | ![]() |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |

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