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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
TP53 p.R273C Reference Standard
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CBP10137
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| Format | Genomic DNA |
| Description | TP53 R273C is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). R273C results in decreased activation of wild-type Tp53 target genes, as well as aberrant activation of gene expression, and increased cell proliferation and migration in culture (PMID: 23264849, PMID: 23612969, PMID: 16861262). |
| Technical Data | |
| DNA Change: | c.817C>T |
| AA Change | p.R273C |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM10659 |
| Chr position(GRCh37) | chr17:7577121 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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