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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
TP53 p.C135Y Reference Standard
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CBP10168
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| Format | Genomic DNA |
| Description | TP53 C135Y lies within the DNA-binding domain of the Tp53 protein (UniProt.org). C135Y confers a loss of function to the Tp53 protein as demonstrated by loss of binding to the Drosha complex and inability to induce downstream miRs and loss of transactivation activity in cell culture (PMID: 19626115, PMID: 8336941). |
| Technical Data | |
| DNA Change | c.404G>A |
| AA Change | p.C135Y |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM10801 |
| Chr position(GRCh37) | chr17:7578526 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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