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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
BRAF p.L597V Reference Standard
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CBP10241
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| Format | Genomic DNA |
| Description | BRAF L597V lies within the protein kinase domain of the Braf protein (UniProt.org). L597V results in activation of Braf as indicated by increased phosphorylation of Mek and Erk in cell culture (PMID: 22798288) and and induces cell proliferation and cell viability in culture (PMID: 29533785). |
| Technical Data | |
| DNA Change | c.1789C>G |
| AA Change | p.L597V |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 33.33% |
| Transcript | ENST00000288602 |
| Cosmic ID | COSM470 |
| Chr position(GRCh37) | chr7:140453146 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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